The brand new unstratified Kaplan–Meier estimators revealed that Operating system try as much as 72% 12 months just after list hospitalization, coming down which have expanded follow-up (61% at the dos-seasons and you will 37% at the 5-year realize-up). Female CLTI patients demonstrated straight down endurance rates compared to men clients (Figure 1A and find out Supplementary situation on the internet , Desk S4 ) plus the impact the death is high in females was supported by the new Kaplan–Meier curves independently of your own RF (select Additional topic on the internet , Shape S3A–D ). But, if whole cohort is actually classified in different age groups (?39, 40–49, 50–59, 60–69, 70–79, 80–89, and you will ?ninety ages), female CLTI patients showed a decreased death rate in all age organizations (Shape 1B–H). This new Kaplan–Meier estimators of one’s years- and you may RF-paired cohort demonstrated large mortality prices for males (pick Second thing on line , Dining table S4 ). Furthermore, nearly you to-6th underwent an amputation of your own LL in the first year once directory hospitalization having ascending viewpoints in addition to probability for amputation is actually low in female CLTI people compared with men (select Supplementary material online , Desk S4 and Profile S3E–H ).